Author/Authors :
QI, Li Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China , QI, Xiaoling Dept. of Dental Medicine - Sichuan University, Chongqing, China , XIONG, Hongyan Dept. of Military Epidemiology - Third Military Medical University, Chongqing, China , LIU, Qin Dept. of Public Health - Chongqing University of Medical Science, Chongqing, China , LI, Jinxin Jiangsu Municipal Center for Disease Control and Prevention, Nanjing, China , ZHANG, Yao Dept. of Military Epidemiology - Third Military Medical University, Chongqing, China , MA, Xiangyu Dept. of Military Epidemiology - Third Military Medical University, Chongqing, China , WU, Na Dept. of Military Epidemiology - Third Military Medical University, Chongqing, China , LIU, Qingyun Dept. of Military Epidemiology - Third Military Medical University, Chongqing, China , FENG, Liangui Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China
Abstract :
Background: Epidemiology studies have demonstrated inconsistent associations between type 2 diabetes mellitus and
the risk of malignant melanoma. To this end, the aim was to perform a meta-analysis of cohort studies.
Method: Medline, PubMed, Embase and the Cochrane Library were searched up to February 2014. Cohort studies
addressing the relative risk of type 2 diabetes mellitus on malignant melanoma were included in this meta-analysis. The
Newcastle-Ottawa Scale was applied for quality evaluation. The pooled relative risks with the corresponding 95% confidence
intervals (95% CIs) were calculated by using random-effects or random-effects model. Heterogeneity and publication
bias were evaluated by I2 and funnel plot analysis, respectively. Data was analyzed using STATA 11.0.
Results: A total of 9 independent cohorts from 8 manuscripts were entered this meta-analysis. Type 2 diabetes mellitus
was slightly associated with an increased risk of malignant melanoma, and the pooled relative risk was 1.15 (95%
CI, 1.00-1.32) in diabetes compared with non-diabetes with significant evidence of heterogeneity among these studies
(P=0.016, I2 =57.6%). For the studies adjusted for age, gender and obesity, the relative risks were 1.21 (95% CI, 1.03-
1.42), 1.17 (95% CI, 1.01-1.35) and 1.11 (95% CI, 1.00-1.24), respectively. For the population-based studies in which
case cohort established, the relative risk was 1.85 (95% CI, 1.31-2.62).
Conclusion: Type 2 diabetes might be an independent risk factor for malignant melanoma. Further studies are needed
to specifically test the effect, and fully elucidate the underlying pathophysiologic mechanisms
