Title of article :
Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress
Author/Authors :
Younessi, Parisa Centre for Complementary Medicine Research - University of Western Sydney - Campbelltown Campus - Sydney - Australia. Faculty of Applied Science - University of Canberra - Canberra - Australia. , Yoonessi, Ali Department of Neuroscience - School of Advanced Medical Technologies - Tehran University of Medical Science - Tehran - Iranian National Center for Addiction Studie - Tehran University of Medical Sciences - Tehr
Abstract :
Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alz-heimer’s disease (AD). Activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progression of AD. It is also suggested that interaction between an advanced glycation end product (AGE) and its receptor (RAGE) results in glial activation as well as cy-tokine release and reactive oxygen species release. The use of antioxidants, receptor mediated compounds and reactive oxygen species scavenging enzyme produce an opportunity to in-tervene with AGE-RAGE signaling pathway, and thereby to slow down the progression of aging-related diseases.
Keywords :
Advanced glycation end producs , receptor for advanced glycation end products , oxidative stress , inflammation , signaling pathway
Journal title :
Astroparticle Physics
