Author/Authors :
Mashayekhi Goyonlo, Vahid Department of Dermatology - Faculty of Medicine - Rsearch Center for Skin Disease and Cutaneous Leishmaniasis - Emam Reza Hospital - Mashhad University of Medical Sciences, Mashhad, IR Iran , Elnour, Hesameldin Department of Medicine - Unit of Dermatology and Venereolog, Stockholm, Sweden , Nordlind, Klas Department of Medicine - Unit of Dermatology and Venereology, Stockholm, Sweden
Abstract :
Objectives: We conducted this study to determine and compare IL-2 expression in lupoid and usual types of Old World Cutaneous Leishmaniasis (OWCL), using immunohistochemistry.
Patients and Methods: Thirteen paraffin-embedded specimens of lupoid and 12 specimens of usual types of OWCL were used. A mouse monoclonal anti IL-2 antibody was used for staining by the envision technique.
Results: There were strongly stained discrete foci of staining through inflammatory infiltrates of dermis and also in basal layers of epidermis and adnexal structures, with a distinctive pattern of hot spot activity foci (mean of 9.31 ± 6.4 versus 8.17 ± 6.9 foci per HPF for lupoid and usual types, respectively). The expression of IL-2 had no correlation with the pattern of granulomatous inflammation (tuberculoid, sarcoidal or mixed suppurative).
Conclusions: Interleukin-2 takes part in the immunological response of the granulomatous reaction of OWCL and is not statistically different between lupoid and usual types (P = 0.674).
