Author/Authors :
Heravian, Javad Department of Optometry - School of Paramedical Sciences - Mashhad University of Medical Sciences , Ehyaei, Akram Department of Optometry - School of Paramedical Sciences - Mashhad University of Medical Sciences , Shoeibi, Nasser Eye Research Center - Khatam-al-Anbia Hospital - Mashhad University of Medical Sciences , Azimi, Abbass Department of Optometry - School of Paramedical Sciences - Mashhad University of Medical Sciences , Ostadi-Moghaddam, Hadi Department of Optometry - School of Paramedical Sciences - Mashhad University of Medical Sciences , Yekta, Abbas-Ali Department of Optometry - School of Paramedical Sciences - Mashhad University of Medical Sciences , Khoshsima, Mohamad Javad Department of Optometry - School of Paramedical Sciences - Mashhad University of Medical Sciences , Esmaily, Habbibolah Department of Biostatistics - School of Health - Mashhad University of Medical Sciences
Abstract :
Purpose: To evaluate cortical and retinal activity by pattern visual evoked potentials
(PVEP) in patients with type II diabetes mellitus.
Methods: PVEP was recorded in 40 diabetic patients including 20 subjects with nonproliferative
diabetic retinopathy (NPDR) and 20 others without any retinopathy on
fundus photography, and compared to 40 age- and sex-matched normal non-diabetic
controls.
Results: P100 wave latency was significantly longer in diabetic patients as compared
to normal controls (P<0.001); both diabetic subjects without retinopathy and those with
NPDR had significantly longer P100 latency than controls (P<0.001 for both comparisons).
There was significant reduction in N75 (P=0.037) and P100 (P=0.001) amplitudes in
diabetic subjects. No correlation was observed between VEP amplitude or wave latency,
and the level of glycemia or duration of diabetes mellitus.
Conclusion: Increased PVEP latency may be a sign of retinal ganglion cell damage which
takes place before the appearance of the first ophthalmoscopically detectable signs of
diabetic retinopathy. PVEP may be considered as a method for detecting prediabetic
retinopathy and has the potential to reduce diabetic complications.
