Title of article
Effect of Aqueous Allium cepa and Ixora brachiata Root Extract on Leishmania major Promastigotes
Author/Authors
Sadeghi Nejad, Batool Department of Medical Mycology - Cellular and Molecular Research Center - Ahvaz Jundishapur University of Medical Sciences , Saki, Jasem Department of Medical Parasitology - Infectious and Tropical Disease Research Center - School of Medicine - Ahvaz Jundishapur University of Medical Sciences , Azish, Maryam Department of Medical Mycology - Ahvaz Jundishapur University of Medical Sciences
Pages
3
From page
1
To page
3
Abstract
Background: Leishmaniasis is a major worldwide public health problem with about two to three million humans threatened by this disease annually. Allium cepa (onion) is an important dietary vegetable and was used as a herbal medicine for centuries. The root of Ixora brachiata is medicinally important.
Objectives: The aim of this study was to investigate the anti-Leishmania effect of the ethanolic and methanolic extracts of Ixora brachiata root and aqueous onion extracts on Leishmania major promastigotes.
Patients and Methods: The parasites isolated from cutaneous leishmaniasis were exposed with different concentrations of selected plant extracts and their inhibitory effects on the promastigotes were evaluated after 24 and 48 hours.
Results: Among tested plant extracts, Ixora brachiata root extracts revealed the best activity against Leishmania major promastigotes with IC100 value of 2.5 mg/mL and IC50 value of 0.078 mg/mL.
Conclusions: This study showed that aqueous Allium cepa and Ixora brachiata root extracts as natural products could be used as alternative drugs in treatment of leishmaniasis.
Keywords
Leishmania major , Allium cepa , Ixora brachiata , Leishmaniasis
Journal title
Astroparticle Physics
Serial Year
2014
Record number
2421284
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