Author/Authors :
Dzhimak, Stepan Sergeevich Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin - V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia , Shikhliarova, Alla Ivanovna Testing Laboratory Centre - Rostov Research Institute of Oncology, Rostov-on-Don, Russia , Zhukova, Galina Vitalievna Testing Laboratory Centre - Rostov Research Institute of Oncology, Rostov-on-Don, Russia , Basov, Alexandr Alexandrovich Department of Radiophysics and Nanotechnology - Kuban State University, Krasnodar, Russia , Kit, Oleg Ivanovich Testing Laboratory Centre - Rostov Research Institute of Oncology, Rostov-on-Don, Russia , Fedulova, Liliya Viacheslavovna Experimental Clinic - Laboratory of Biologically Active Substances of Animal Origin - V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences , Kurkina, Tatiana Anatolievna Testing Laboratory Centre - Rostov Research Institute of Oncology, Rostov-on-Don, Russia , Shirnina, Elena Alekseevna Testing Laboratory Centre - Rostov Research Institute of Oncology, Rostov-on-Don, Russia , Panteleevna, Tatiana Testing Laboratory Centre - Rostov Research Institute of Oncology, Rostov-on-Don, Russia , Baryshev, Mikhail Gennadievich Department of Radiophysics and Nanotechnology - Kuban State University, Krasnodar, Russia , Timakov, Alexandr Alekseevich MTK Iceberg - LLC, Moscow, Russia
Abstract :
Consumption of deuterium depleted water (DDW) (46 2 ppm) as drinking water by white outbred female rats (20 - 22 months)
during five weeks led to the development of a well-pronounced geroprotector effect, which manifested in occurrence of the estrous
cycle restoration signs, as well as in the coat state improvement, compared with the same characteristics of animals that received
drinking water with a deuterium content of 150 ppm. Besides, rats receiving DDW showed the improvement of the skin bactericidal
power. Thus, experiments in mammals provided a direct confirmation of the geroprotector properties of DDW. The current
study revealed a deuterium content reduction in blood (according to theNMR(nuclear magnetic resonance) spectroscopy data) and
visceral organs: liver, kidney, and heart (according to the mass spectroscopy data) in animals receiving DDW. A more pronounced
decrease in the deuterium content was recorded in the rat blood plasma (33.2%) compared with the deuterium content changes in
visceral organs (liver -7.2%, kidney -9.7%, heart -7.3%), which generally led to a change in the direction of the D/H isotopic gradient
with consumption of DDW by the animals (CDblood plasma < CDvisceral organs).
Keywords :
Deuterium , NMR Spectroscopy , Geroprotector Effect , Anti-Stress Effect , Anti-Stress Adaptation
