Protective Effect of Ocimum sanctum on Disposition Kinetics of Sulphadimidine in Lead-Treated Cockerel

This study was carried out to evaluate the protective effect of Ocimum sanctum (tulsi) on lead-induced alteration in disposition kinetics of sulphadimidine (SD) in cockerels. Twenty-one, four-week male white leghorn (WLH) chicks were randomly divided into groups I, II and III (7 in each) and were fed at dietary with 0 ppm lead and no tulsi (group I, Control), 100 ppm lead (group II), or 100 ppm lead + 100 ppm tulsi (group III). After four weeks, disposition kinetics of intravenous single dose administration of SD (50 mg /kg) was determined in each bird. The mean values of elimination half-life, distribution–half, AUC, and volume of distribution were significantly (p<0.01) higher in lead-treated group than those in lead plus tulsi group (III) The clearance (Cl, mL/kg/h) of SD was slower in lead-treated groups than lead plus tulsi and control groups The priming dose of SD (mg/kg) in chicks following single i.v. administration is proposed as 68.91 and 122.57 for group I (control), 51.42 and 79.21 for group II (lead) and 61.38 and 106.59 for group III (lead plus tulsi), at 8 h and 12 h interval, respectively. The maintenance doses (Dm, mg/kg) were minimum in group II (39.31 and 57.54) followed by group III (41.03 and 86.25) and control (47.13 and 100.80) at 8 and 12h interval, respectively. It is concluded that feeding of lead at 100 ppm dietary level altered the kinetics and dosage regimen of SD which were significantly ameliorated following simultaneous feeding with powdered tulsi (100ppm) in cockerels.