Author/Authors :
PRASANNA KUMAR, K. Department of Pharmacology - Vel’s college of Pharmacy, Chennai, India , RAMA NARSIMHA REDDY, A Department of Pharmacology - University College of Pharmaceutical Sciences - Kakatiya University, Warangal, India , NARSIMHA REDDY, Y Department of Pharmacology - University College of Pharmaceutical Sciences - Kakatiya University, Warangal, India , ANBU, J. Department of Pharmacology - Vel’s college of Pharmacy, Chennai, India
Abstract :
The present study was aimed at evaluating the lipid lowering activity of lercanidipine, a calcium channel
blocker, in standard diet induced hyperlipidemic rats. Hyperlipidemic rats were divided into different
groups and were treated with daily oral dose of lercanidipine and atorvastatin for 7 days. On 8th day,
blood samples were collected and analyzed for serum lipid levels using commercial kits. The rats were
fed with standard cholesterol diet to induce hyperlipidemia. The effect of lercanidipine on lipid profiles in
hyperlipidemic rats was estimated. Like atorvastatin, a standard lipid lowering drug, lercanidipine reduced
the cholesterol, triglycerides and low density lipoprotein levels. These findings suggest that antihyperlipidemic
activity of lercanidipine, which may be used for the treatment of various cardiovascular
diseases associated with hyperlipidemia.
Keywords :
Lercanidipine , Lipid lowering activity , Hyperlipidemic rats , Atorvastatin
