Title of article
Antioxidant Activity of Eclipta alba L. in Normal Rat Liver
Author/Authors
SANDEEP MAJUMDAR, A Department of Pharmacology - Bombay College of Pharmacy, Mumbai, India , NATVARLAL SARAF, M Department of Pharmacology - Bombay College of Pharmacy, Mumbai, India , YADAV KAMBLE, R. Department of Pharmacology - Bombay College of Pharmacy, Mumbai, India
Pages
3
From page
103
To page
105
Abstract
The present study investigated the antioxidant potential of the ethyl acetate fraction of the aerial parts
Eclipta alba L. Hassk (EA) which was widely used as hepatoprotective plant. EA was orally administered
at doses of 50, 100 and 200 mg/kg (n=6) for 7 days in male Charles Foster rats. The extent of
hepatoprotective potential of E. alba was studied by assessing the biochemical parameters like lipid
peroxides (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx),
glutathione reductase (GR), ascorbic acid and α-tocopherol in the liver of rats. Oral administration of the
EA significantly decreased LPO and elevated the activity of antioxidant enzymes SOD, CAT, GPx and GR
as well as endogenous levels of ascorbic acid and α-tocopherol in the liver of male Charles Foster rats.
This study has revealed the significant antioxidant potential of E. alba in rat liver.
Keywords
Rat Liver , Antioxidant Activity
Journal title
Astroparticle Physics
Serial Year
2010
Record number
2421683
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