Anti-depressant effects of Baluchi's formulation on spatial learning and memory

Baluchi's formulation is an herbal blend including Date, Almond, Cinnamon, and Pumpkinseed, which have the Powerful antioxidant role and stimulate the brain to produce neurotransmitters. Cholinergic system plays an important role in learning and memory. Prescribing Baluchi's formulation is effective in animal cognitive behavior. The aim of this study was to evaluate the effects of antidepressant By Baluchi's formulation compound on decreased memory due to scopolamine in mice by relying on behavioral tests. It has also been observed that anticholinergic medicines such as scopolamine may cause disorder in the consolidation process in the memory of human beings and animals. So 40 Albino mice (25-30 g) were divided into five groups (+ & - controls and three treatments). During seven consecutive days, the mice received Baluchi's formulation (1, 2, 4 g/kg oral) thirty minutes before scopolamine (1mg/kg i.p.). At the same time, spatial memory and depression parameters were measured using MWM and EPM. The results showed that Baluchi's formulation treatments, significantly increased the time of animal presence in the target quadrant, the percentage of open arms and the time spent in the open arm compared with the control groups (p<0.001). The results of this study showed that the compounds in the Baluchi's formulation micronutrients may be effective in preventing and treating disorders such as depression and demands.