Author/Authors :
Noshad, Hamid Division of Nephrology - Drugs Applied Research Center - Faculty of Medicine - Tabriz University of Medical Sciences , Argani, Hassan Division of Nephrology - Department of Medicine - Shahid Beheshti University of Medical Sciences, Tabriz, Iran , Nezami, Nariman Drugs Applied Research Center - Faculty of Medicine - Tabriz University of Medical Sciences , Ghojazadeh, Morteza Drugs Applied Research Center - Faculty of Medicine - Tabriz University of Medical Sciences , Zomorrodi, Afshar Department of Urology - Faculty of Medicine - Tabriz University of Medical Sciences , Bohlouli, Abolfazl Department of Urology - Faculty of Medicine - Tabriz University of Medical Sciences , Bonyadi, Mohammad Reza Drugs Applied Research Center - Faculty of Medicine - Tabriz University of Medical Sciences , Fakhrjou, Ashraf Department of Pathology - Faculty of Medicine - Tabriz University of Medical Sciences , Ghorbanihaghjo, Amir Drugs Applied Research Center - Faculty of Medicine - Tabriz University of Medical Sciences , Gharedaghi, Abasat Department of Surgery - Faculty of Medicine - Tabriz University of Medical Sciences , Javadzadegan, Hassan Division of Cardiology - Department of Medicine - Faculty of Medicine - Tabriz University of Medical Sciences, , Sadreddini, Shahram Division of Rheumatology - Department of Medicine - Tabriz University of Medical Sciences
Abstract :
Instruction. We investigated the correlation between atherosclerosis
and tissue and serum levels of endothelin-1 in patients with chronic
kidney disease (CKD).
Materials and Methods. Arterial samples were obtained from 35
patients with CKD during arteriovenous fistula placement. Thirtyone
patients with cardiovascular disease who underwent coronary
artery bypass graft (CABG) were selected as the atherosclerotic
group, and a piece of their aorta punched during CABG was
obtained. Also, a small piece of the renal artery was dissected during
donation in 24 kidney donors (control group). Tissue endothelin-1
level was measured and atherosclerosis grading was determined
by pathologic examination. Serum levels of endothelin-1 were also
measured in the three groups.
Results. The mean tissue endothelin-1 levels were 10.73±7.57 pg/
mL, 12.16 ± 3.95 pg/mL, and 0.93 ± 1.06 pg/mL in the patients
with CKD, those with CABG, and donors, respectively (P < .001).
The mean serum endothelin-1 level was 25.23 ± 15.15 pg/mL in the
patients with CKD, 21.13 ± 17.22 pg/mL in the patients with CABG,
and 2.66 ± 1.51 pg/mL in the donors (P < .001). Atherosclerosis
grades correlated with tissue endothelin-1 level (r = 0.823, P < .001)
and serum endothelin-1 level (r = 0.608, P < .001) in the patients
with CKD. Multiple regression analysis showed tissue endothelin-1
level as the main predicting factor of atherosclerosis (P < .001).
Conclusions. Tissue endothelin-1 concentration is more important
than serum endothelin-1 or lipids levels in prediction of
atherosclerosis. Thus, blockade of tissue endothelin-1 receptors
with its antagonists may prevent atherosclerosis progression.
