Title of article :
Posttransplant Lymphoproliferative Disorders
Author/Authors :
Chughtai, Asim Division of Nephrology - Department of Internal Medicine - Saint Louis University School of Medicine, Saint Louis, Missouri, USA , Bastani, Bahar Division of Nephrology - Department of Internal Medicine - Saint Louis University School of Medicine, Saint Louis, Missouri, USA
Abstract :
Posttransplant lymphoproliferative disorder is a heterogenous group
of clonal hyperplasia/neoplasms that can range from benign to
highly malignant lesions. Mortality rates can approach 60%. This
entity has been on the rise for the last 2 decades with the advent
of highly potent immunosuppressive agents. Epstein-Barr virus
has shown to play a primary role in more than 90% of the cases.
Although standard protocols do not exist for primary prevention
and treatment, new agents are emerging that may play a role in
treatment and prevention of this debilitating, and at times, fatal
disease.
Keywords :
lymphoproliferative disorder , organ transplantation , neoplasms , Epstein-Barr virus infections
Journal title :
Astroparticle Physics
