Title of article
Investigate the Role of Glutathione S Transferase (GST) Polymorphism in Development of Hypertension in UAE Population
Author/Authors
Hussain, Kosar Rashid Hospital - Dubai Health Authority, Dubai, United Arab Emirates , Salah, Neveen Department of Biochemistry - Dubai Medical College, Dubai, United Arab Emirates , Hussain, Sahar UAE University - Faculty of Medicine & Health Sciences, Al Ain, United Arab Emirates , Hussain, Sara Dubai Medical College - Dubai, United Arab Emirates
Pages
5
From page
479
To page
483
Abstract
Background: GST is a family of enzymes that are important in protection of the body against oxidative stress.
Objectives: Investigate the association between GSTT1 and GSTM1 polymorphism and hypertension.
Materials and Methods: GSTT1 and GSTM1 genotypes were detected by PCR. The fragments were then analyzed by
agarose gel electrophoresis.
Results: There is no significant association between GSTT1 & GSTM1 polymorphism and hypertension (OR = 2.4, P > 0.05
and or = 1.6, P > 0.05)
Conclusions: GSTT1 & GSTM1 polymorphism can be considered a risk factor for hypertension.
Keywords
Hypertension , Glutathione S-Transferase T1 , Polymorphism , Genetic
Journal title
Astroparticle Physics
Serial Year
2012
Record number
2422047
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