Author/Authors :
Hosseini, Hamid Glaucoma Division - Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA , Nilforushan, Naveed Glaucoma Division - Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA , Moghimi, Sasan Glaucoma Division - Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA , Bitrian, Elena Glaucoma Division - Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA , Riddle, Jay Glaucoma Division - Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA , Yoo Lee, Gina Glaucoma Division - Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA , Caprioli, Joseph Glaucoma Division - Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA , Nouri-Mahdavi, Kouros Glaucoma Division - Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA
Abstract :
Purpose: To compare choroidal thickness (CT) between individuals with and without
glaucomatous damage and to explore the association of peripapillary and submacular CT
with glaucoma severity using spectral domain optical coherence tomography (SD-OCT).
Methods: Ninety-one eyes of 20 normal subjects and 43 glaucoma patients from the
UCLA SD-OCT Imaging Study were enrolled. Imaging was performed using Cirrus HDOCT.
Choroidal thickness was measured at four predetermined points in the macular
and peripapillary regions, and compared between glaucoma and control groups before
and after adjusting for potential confounding variables.
Results: The average (± standard deviation) mean deviation (MD) on visual fields was
−0.3 (±2.0) dB in controls and −3.5 (±3.5) dB in glaucoma patients. Age, axial length
and their interaction were the most significant factors affecting CT on multivariate
analysis. Adjusted average CT (corrected for age, axial length, their interaction, gender
and lens status) however, was not different between glaucoma patients and the control
group (P=0.083) except in the temporal parafoveal region (P=0.037); nor was choroidal
thickness related to glaucoma severity (r=−0.187, P=0.176 for correlation with MD,
r=−0.151, P=0.275 for correlation with average nerve fiber layer thickness).
Conclusions: Choroidal thickness of the macular and peripapillary regions is not
decreased in glaucoma. Anatomical measurements with SD-OCT do not support the
possible influence of the choroid on the pathophysiology of glaucoma.
Keywords :
Glaucoma , Spectral-Domain Optical Coherence Tomography , Choroidal Thickness , Peripapillary , Macula
