Title of article
Synthesis and evaluation of MePEG-PCL diblock copolymers: surface properties and controlled release behavior
Author/Authors
Mohanty, Anjan Kumar Department of Pharmacy - Annamalai University , Jana, Utpal Department of Pharmacy - Annamalai University , Manna, Prabal Kumar Department of Pharmacy - Annamalai University , Mohanta, Guru Prasad Department of Pharmacy - Annamalai University
Pages
12
From page
89
To page
100
Abstract
The amphiphilic block copolymers are composed
of various combinations of hydrophilic and hydrophobic
block unimers. The variation in unimer ratio alters the surface
aswell asmicelle-forming properties of the block copolymers.
These nanoscopic micelles have the ability to encapsulate
hydrophobic compounds and act as potential drug carrier.
MePEG-PCL copolymers with various block lengths were
synthesized by ring-opening polymerization and characterized
by 1HNMR, GPC, WXRD and DSC. The number average
molecular weight of the block copolymer was found to
vary from 7511 to 21,270 as determined by GPC and 1HNMR
studies. The surface topology of the polymer films was
determined by AFM analysis, which shows a smoother surfacewith
increased MePEG contents in the block copolymers.
The protein-binding assay indicates a better biocompatibility
of the block copolymers in comparison to MePEG or PCL
alone. The CMC of the block copolymer provides the information
about micelle formations for encapsulation of
hydrophobic materials and affects the in vitro release.
Keywords
EPR effect , CMC , Micelle , Drug carrier , Biodegradable polymers
Journal title
Astroparticle Physics
Record number
2422580
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