Author/Authors :
Shahramian, Iraj Department of Pediatric - Zabol University of Medical Sciences , Dehghani, Mohsen Department of Pediatric Gastroenterology - Shiraz University of Medical Sciences , Haghighat, Mahmood Department of Pediatric Gastroenterology - Shiraz University of Medical Sciences , Noori, Noor Mohammad Department of Pediatric Cardiology - Children and Adolescents Health Research Center - Zahedan University of Medical Sciences , Teimouri, Alireza Children and Adolescents Health Research Center - Zahedan University of Medical Sciences , Sharafi, Elham Resident of Ophthalmology - Zahedan University of Medical Sciences , Kalili, Manijeh Department of Pediatric Gastroenterology - Children and Adolescents Health Research Center - Zahedan University of Medical Sciences , Kalvandi, Gholamreza Fellow of Pediatric Gastroenterology - Department of Pediatric Gastroenterology - Shiraz University of Medical Sciences
Abstract :
BACKGROUND
Due to the increased prevalence of celiac disease in chromosomal anomalies
and other congenital anomalies, this study was conducted to evaluate the
seroprevalence of celiac disease (CD) in patients with congenital heart defects
(CHD).
METHODS
This case-control study was done on 1002 children in two groups of CHD
patients (n=402) and controls (n=600). The serum tissue transglutamianse
(TTG) levels were investigated. The two groups were compared in terms of
TTG IgA levels and p<0.05 was considered as the significant level.
RESULTS
The means of serum TTG IgA levels in children with CHD and the control
groups were 19.17±46.67 and 7.77±10.02 u/mL respectively (p=0.001). After
ANOVA analysis a significant difference between two cyanotic and acyanotic
subgroups of cases and control groups was observed (p=0.000). The follow up
tukey test showed only non-significant difference between the cyanotic and
acyanotic cases. The frequency of TTG IgA with the consideration of 20 u/mL
as cut-off point showed a significant association with groups (X2=28.31 and
p=0.000).
CONCLUSION
According to the results the serum TTG IgA levels were significantly higher
in patients with CHD than normal children and screening for CD in children
with CHD is recommended.
Keywords :
Children , Heart Defect , Congenital , Celiac disease
