Title of article :
A green four-component synthesis of 2-amino-3-cyano-4-aryl-6-sulfanepyrimidine in water solvent using phase-transfer catalyst
Author/Authors :
Xu, Liang National Research Center for Carbohydrate Synthesis and Key Laboratory of Chemical Biology - Jiangxi Normal University , Gu, Chenghao National Research Center for Carbohydrate Synthesis and Key Laboratory of Chemical Biology - Jiangxi Normal University , Li, Rou National Research Center for Carbohydrate Synthesis and Key Laboratory of Chemical Biology - Jiangxi Normal University , Yu, Yikai National Research Center for Carbohydrate Synthesis and Key Laboratory of Chemical Biology - Jiangxi Normal University , Wang, Tao National Research Center for Carbohydrate Synthesis and Key Laboratory of Chemical Biology - Jiangxi Normal University
Abstract :
New green one-pot four-component reactions of thiourea, malononitrile halohydrocarbon, aldehydes and alkyl halide have been successfully developed in eco-friendly water solvent through available phase-transfer catalyst, to access high yields of 2-amino-3-cyano-4-aryl-6-sulfanepyrimidines.
Keywords :
Multicomponent reactions , Water solvent , Pyrimidine derivatives , Knoevenagel reaction
Journal title :
Astroparticle Physics
