Author/Authors :
Zhi-Wen, Yang Department of Pharmacy, Songjiang Hospital Affiliated Shanghai First People’s Hospital, Shanghai Jiao Tong University Shanghai, China , Yan-Li, Zhang Department of Pharmacy, Songjiang Hospital Affiliated Shanghai First People’s Hospital, Shanghai Jiao Tong University Shanghai, China , Man, Yuan Department of Pharmacy, Songjiang Hospital Affiliated Shanghai First People’s Hospital, Shanghai Jiao Tong University Shanghai, China , Wei-Jun, Fang Department of Pharmacy, Songjiang Hospital Affiliated Shanghai First People’s Hospital, Shanghai Jiao Tong University Shanghai, China
Abstract :
Objective: Pandrug-resistant (PDR) bacterial infections are associated with considerable prolongation of hospitalization and mortality in clinical practice. Method: This case-series study was conducted during a 3-year period from 2011 to 2013. A total of 30 PDR patients consulted by clinical pharmacist were recorded to evaluate the anti-infection treatment. Results: All isolates of PDR bacteria from patients were identified as pan-drug resistant acine-tobacter baumannii (63.3%), pan-drug resistant klebsiella pneumonia (20.0%), and pandrug- resistant pseudomonas aeruginosa (16.7%). Of the 30 patients, 96.7% therapeutic regimens supposed by clinical pharmacists were applied to treat the infectious patients up to 82.8% clinical cure rates. 30 patients completed the prescribed treatment, of which 19 underwent monotherapy that the clinical cure rate was 78.9%, and 10 underwent combination therapy that the clinical cure rate was 90.0%. In the following therapy, doxycycline, cefoperazone shubatan and amikacin have the certain effect on anti-infection therapy. Combination therapy combined with doxycycline was better treatment option for PDR infectious patients. Conclusion: In a word, it appears to be effective for the successful therapy of PDR infections upon tetracyclines administration.
