Title of article :
A green protocol for the one-pot multicomponent Petasis boronic Mannich reaction using ball milling
Author/Authors :
Hosseinzadeh, R Department of Organic Chemistry - Faculty of Chemistry - University of Mazandaran , Lasemi, Z Department of Chemistry - Firoozkooh Branch Islamic Azad University , Oloub, M Department of Organic Chemistry - Faculty of Chemistry - University of Mazandaran , Pooryousef, M Department of Organic Chemistry - Faculty of Chemistry - University of Mazandaran
Abstract :
Solvent-free reactions of salicylaldehyde with various boronic acids and amines were accomplished under ball-milling conditions to achieve the corresponding alkyl- and arylaminophenols in good to excellent yields. This simple protocol offers advantages such as high yields, shorter reaction times, simple workup procedure and eco-friendliness.
Keywords :
Ball milling , Petasis boronic Mannich reaction , Amines , Boronic acids , Salicylaldehyde
Journal title :
Astroparticle Physics
