Title of article :
Immobilized [Cu(cdsalMeen)] on silica gel: a highly efficient heterogeneous catalyst for ‘Click’ [3 + 2] Huisgen cycloaddition
Author/Authors :
Zarenezhad, Elham Non-communicable Diseases Research Center - School of MedicineFasa University of Medical Sciences , Soltani Rad, Mohammad Navid Medicinal Chemistry Research Laboratory - Department of Chemistry - Shiraz University of Technology , Behrouz, Somayeh Medicinal Chemistry Research Laboratory - Department of Chemistry - Shiraz University of Technology , Esmaielzadeh, Sheida Department of Chemistry - Darab BranchIslamic Azad UniversityDarab , Farjam, Mojtaba Non-communicable Diseases Research Center - School of MedicineFasa University of Medical Sciences
Abstract :
A facile and simple protocol for the ‘Click’ cycloaddition of organic azides with terminal alkynes catalyzed by immobilized [Cu(cdsalMeen)] on silica as a new and convenient heterogeneous catalyst is described. In this synthetic methodology, [Cu(cdsalMeen)]–SiO2 catalyzes 1,3-dipolar Huisgen cycloaddition of different functionalized β-azido alcohols and alkynes in the presence of ascorbic acid and a solution of THF/H2O (2:1, V/V) at room temperature. Good to excellent yields of β-hydroxytriazolylalkyl derivatives were afforded using [Cu(cdsalMeen)]–SiO2. Immobilization of [Cu(cdsalMeen)] on silica was approved as a chemically and thermally stable catalyst that can be reused for many consecutive trials without a significant decline in its reactivity.
Keywords :
Click’ cycloaddition , Heterogeneous catalyst , β-azido alcohols , Terminal alkynes , β-hydroxytriazolylalkyl
Journal title :
Astroparticle Physics
