Title of article :
A Clone with 5, 17 and 18 Monosomies as Stemline in a Patient with De novo Acute Myeloid Leukemia
Author/Authors :
Zare-Abdollahi, Davood Department of Medical Genetics - Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Movafagh, Abolfazl Department of Medical Genetics - Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Safari, Shamsi Department of Medical Genetics - Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Omrani, Davood Department of Medical Genetics - Faculty of Medicine - Shahid Beheshti University of Medical Sciences
Abstract :
In brief, we present a case of acute myeloid leukemia (AML) with 5, 17 and 18 monosomies as stemline clonal abnormality in his cytogenetic analysis. To the best of our knowledge, this is the first report of such a chromosomal abnormality as a clonal aberration in AML with MO French-American-British (FAB) type. It seems that this monosomal karyotype imposed adverse prognosis on this patient and could be related to the rapid and malignant course of the disease as seen.
Keywords :
stemline , monosomy , karyotype , Acute myeloid leukemia (AML)
Journal title :
Astroparticle Physics
