Author/Authors :
Oraki Kohshour, Mojtaba Department of Immunology - School of Medicine - Ahvaz Jundishapur University of Medical Sciences, Ahvaz , Galehdari, Hamid Department of Genetics - Faculty of Science - Chamran University of Ahvaz, Ahvaz , Foroughmand, Ali Mohammad Department of Genetics - Faculty of Science - Chamran University of Ahvaz, Ahvaz , Andashti, Behnaz Department of Genetics - Faculty of Science - Chamran University of Ahvaz, Ahvaz , Jalalifar, Mohammad Ali Iranian Blood Transfusion Organization Research Center, Ahvaz , Bidmeshkipour, Ali Department of Biology - Faculty of Science - Razi University, Kermanshah
Abstract :
In most Asian countries, with a general carrier
rate of 5%–35%, hepatitis B virus (HBV)
infection is hyperendemic (1). HBV is a member of
Hepadnaviridae, a family of enveloped hepatotropic
DNA viruses. It has a circular, partially doublestranded
DNA of 3200 nt (2). This virus can cause
severe liver disease with eventual progression to
cirrhosis and primary hepatocellular carcinoma
(HCC) (3). HBV possesses a high genetic variability
which gives rise to the well-recognized subtypes
and genotypes of the virus. In addition, many virus
variants are arisen during replication, as a result
of nucleotide misincorporation, for lack of any
proof-reading mechanisms in the viral polymerase
(4). Therefore, genotyping of HBV is important
in determining the route and pathogenesis of the
virus. Particular attention has been paid to the
differences between the HBV genotypes. It has
become increasingly evident that the heterogeneity
in the global distribution of HBV genotypes and
their sub-genotypes may account for differences in
the prevalence of mutations in various populations,
the clinical outcomes of HBV infections, and the
response to antiviral therapy.
There are several methods
Keywords :
HBV , HBsAg-Positive , Blood , Southwestern
