Author/Authors :
Farajirad, Elnaz Head of Ghaem Health Center - Mashhad University of Medical Sciences, Mashhad, Iran , Ghaemi, Kazem Head of Neurosurgery Department - Faculty of Medicine - Birjand University of Medical Sciences, Birjand, Iran , Khajavi, Mehdi Neurosurgery Department - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Hamidi Alamdari, Daryoush Stem Cell and Regenerative Medicine Research Group - Biochemistry & Nutrition Research Center - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Arjmand, Mohammad Hassan Surgery Department - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Farajirad, Mohammad Head of Neurosurgery Department - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract :
Background & Aim: The most common primary brain tumors of the central nervous system are gliomas. Among a
number of different biomolecular events, a strong relation between oxidative stress pathways and the development
of this cancer has been proved. Oxidative stress (OS) is the consequence of an imbalance between pro-oxidants
and antioxidants towards pro-oxidants. The pro-oxidants cause lipid peroxidation of cell membranes, protein, DNA
oxidation and changes in brain cell growth. In this study, the pro-oxidant–antioxidant balance (PAB) was determined
in patients with gliomas.
Methods & Materials/Patients: Sera of 49 patients with high grade glioma (grade IV WHO) which is called
glioblastoma multiform (GBM) and 49 healthy subjects were collected and PAB test was measured.
Results: A significant increase of PAB value was observed in patients with GBM (158.10±85.71 HK unit) in comparison
to control group (74.54±33.54 HK).
Conclusion: The PAB assay showed the oxidative stress in glioblastoma. In further research, this easy elucidation of
oxidative stress in these patients can be applied to evaluate the effectiveness of antioxidant therapies in patients with
GBM.
