Author/Authors :
Hamed, Galil Maged Abdel Radiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt , Abdel Ghany, Ahmed Fathy Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract :
Introduction: Brain imaging with F-18 fluorodeoxyglucose (18F-FDG) positron emission tomography or Tc-99m
hexamethylpropyleneamine oxime (99mTc-HMPAO) SPECT is widely used for the evaluation of Alzheimer's dementia (AD); we
aim to assess superiority of one method over the other.
Methods: Twenty four patients with clinical diagnosis of Alzheimer disease underwent 18F-FDG PET and 99mTc-HMPAO SPECT
in order to assess the zones of hypo metabolism & hypoperfusion specific for Alzheimer's disease.
Results: 18F-FDG PET showed specific zones of hypometabolism in 19 patients (79.1%) while SPECT was positive in 15 cases
(62.5%) with statistically significant difference (P= 0.027).
Conclusion: 18F-FDG PET was significantly superior to HMPAO SPECT and 18F-FDG PET could replace the classic role of
perfusion SPECT in diagnosis of Alzheimer's disease.
Keywords :
PET , SPECT , HMPAO , Alzheimer's disease
