Dietary and the Risk of Sporadic Colorectal Cancer in China: A Case-control Study

Background: High-fat diets have been considered a risk factor for sporadic colorectal cancer (CRC) in West-ern countries. However, data for this phenomenon are lacking in China. The purpose of this study was to com-prehensively evaluate the association between diet and the risk for sporadic CRC in Shandong Province, China. Methods: In this case-control study, 317 patients with sporadic CRC and 317 controls were collected in Shan-dong Province, China. All the samples were collected on the basis of rigorous screening criteria. The data were analyzed using a χ2 test, univariate or multivariate conditional logistic regression, and stratified analysis. Results: Multivariate logistic regression showed that the following are risk factors for sporadic CRC (all P<0.05): consumption of pork, fried food or barbecued meat; high Body Mass Index (BMI); alcohol abuse; psychosis; and the presence of a factory causing pollution near the home. Moreover, univariate analysis revealed the following qualities were also positively associated with CRC (all P<0.05): intake of animal oil, consuming brawn and kipper, smoking, exhibiting frequent anger, and poor sleep quality. Eating fresh fruit was inversely correlated with the incidence of CRC (P=0.012). Further stratified analysis demonstrated that BMI and the con-sumption of fried food, barbecued meat, or garlic were correlated with colon cancer. However, alcohol abuse and psychosis were related to an increased risk for rectal cancer. Conclusion: Dietary factors are related to sporadic CRC in Shandong Province. Future interventions should focus on reducing the related risk factors while advocating for practice of the protective factors.