Author/Authors :
SHABANI AZIM, Faezeh Student Scientific Research Center - School of Allied Medical Sciences - Tehran University of Medical Sciences, Tehran, Iran , HOURI, Hamidreza Dept. of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , GHALAVAND, Zohreh Dept. of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , NIKMANESH, Bahram Dept. of Medical Laboratory Sciences - School of Allied Medical Sciences - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Background: The aim of this mini-review is to highlight the potential applications of next-generation sequencing technology to the field of clinical oncology with respect to genetic diagnosis, cancer classification, predictive bi-omarkers and personalized medicine.
Methods: Scientific databases were searched to collect relative data.
Results: Effective systematic analysis of whole-genome sequence and whole-exome sequence of tumors, targeted genome profiling, transcriptome sequencing and tumor- normal comparisons can be performed using NGS in order to diagnosis of several types of cancer.
Conclusion: NGS technology can be powerful enough to discover new and infrequent gene alterations, identify hereditary cancer mutation carriers and provide a reliable molecular portrait of wide range of cancers in a quick and cost-effective manner.
Keywords :
Next generation sequencing , Cancer , Genetic diagnosis , Biomarkers , Personalized medicines
