Author/Authors :
Ragi, A.S Department of Chemical Oceanography - Faculty of Marine Sciences - Cochin University of Science and Technology, Cochin-682016, India , Leena, P.P Inter University Center for Development of Marine Biotechnology - Cochin University of Science and Technology, Cochin-682016, India , Prashob, K.J.P Department of Chemical Oceanography - Faculty of Marine Sciences - Cochin University of Science and Technology, Cochin-682016, India , Nair, S.M Department of Chemical Oceanography - Faculty of Marine Sciences - Cochin University of Science and Technology, Cochin-682016, India
Abstract :
Background: The purpose of this study was to investigate the sterol profiling and pre-dict the pharmacological potential of marine gastropod Telescopium telescopium (T. telescopium), collected from mangrove ecosystem in the South west coast of India.
Methods: Sterol fractions were separated from the crude lipids using 15% ethyl ace-tate. Ethyl acetate fractions were dried under ultrahigh purity N2 and analyzed using GC-MS. The biological activity was predicted using the software CLC-Pred; In silico predictions of cytotoxicity for tumor and non-tumor cell lines and PASS.
Results: This study proved the existence of four sterols, of which cholesterol was abun-dant. It was found that most of the steroids profiled from T. telescopium displayed ac-tivity against reproductive system as well as skin related diseases.
Conclusion: The predicted anti infertility and skin related activity of the steroids iden-tified from the marine gastropod T. telescopium is useful to attract industrial interest towards this species which will be helpful in rising new combinations with added therapeutic and nutritional worth.
Keywords :
Telescopium telescopium , Sterols , PAAS , CLC-Pred
