High Fat Diet- Induced Neurotoxicity Alters Following vitamin E and C Administration in Hippocampus of Male Rats

Background: Consumption of a high fat diet (HFD) leads to spatial memory impairment and hippocampal cell death. Objectives: The present study evaluated the capacity of antioxidant supplementation to interact with the effects of high fat diet at the molecular level. Methods: Animal groups were exposed to HFD for 9 months with free access to high fat diet and high fat diet with antioxidant supplementation (vitamin E, vitamin C,andAstaxanthin). At the endof the study, brains wereremovedandthe level of brain-derived neurotrophic factor (BDNF), Tropomyosin receptor kinase B (Trk ), synapsin I, and the transcription factor Cyclic AMP Response Element Binding protein (CREB) and caspase-3 expression in the hippocampi were measured. Results: Antioxidants protected against HFD-induced cell death and the up-regulation of BDNF, Trk, Synapsin I, CREB, and Caspase- 3. Conclusions: This data suggested the possible benefit of vitamin E and C in the treatment of neurotoxicity among, those with a HFD.