Author/Authors :
Sargazi, Saman Department of Clinical Biochemistry - School of Medicine - Shahidsadoughi University of Medical Sciences, Yazd, Iran , Saravani, Ramin Cellular and Molecular Research Center and Department of Clinical Biochemistry - School of Medicine - Zahedan University of Medical Sciences, Zahedan, Iran , Galavi, HamidReza Cellular and Molecular Research Center and Department of Clinical Biochemistry - School of Medicine - Zahedan University of Medical Sciences, Zahedan, Iran , Mollashahee-Kohkan, Fatemeh Cellular and Molecular Research Center and Department of Clinical Biochemistry - School of Medicine - Zahedan University of Medical Sciences, Zahedan, Iran
Abstract :
Levisticum officinale contains a variety of components used for its medicinal properties in traditional medicine. The previous studies
showed that it had an anti-cancer effect on cell lines. The current study aims to evaluate the cytotoxic potential of Levisticum officinale
hydroalcoholic extract (LOHE) on DU-145 and PC-3 human advanced prostate cancer cell lines. The anti-proliferative activity of LOHE
was evaluated using the MTT assay. The results of MTT showed that the IC50 of DU-145 and PC-3 were 500 g/mL and 400 g/mL
of LOHE, respectively, following 24 hours treatment. This study found that the hydroalcoholic extract of Levisticum officinale had
beneficial cell death inducing effects on both the PC3 and DU145 human prostate carcinoma cell lines in time- and concentrationdependent
fashion. Hence, LOHE may have remarkable potential for uses as new natural anticancer agent.
Keywords :
Levisticum officinale , Cell Death , Cytotoxic Effects , Prostate Cancer
