Author/Authors :
Soveyd, Neda Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Abdolah, Mina Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Bitarafan, Sama Department of Neurology - Imam Khomeini Hospital - Tehran University of Medical Sciences, Tehran , Tafakhori, Abbas Department of Neurology - Imam Khomeini Hospital - Tehran University of Medical Sciences, Tehran , Sarraf, Payam Department of Neurology - Imam Khomeini Hospital - Tehran University of Medical Sciences, Tehran , Togha, Mansoureh Tehran University of Medical Sciences, Tehran , Okhovat, Ali Asghar Tehran University of Medical Sciences, Tehran , Hatam, Mahsa Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Sedighiyan, Mohsen Department of Clinical Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Djalali, Mahmoud Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Mohammadzadeh-Honarvar, Niyaz Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran
Abstract :
Migraine is a common chronic inflammatory neurological disease with the progressive and episodic course. Much evidence have shown a role of inflammation in the pathogenesis of migraine. Omega-3 fatty acids are an important components of cell membranes phospholipids. The intake of these fatty acids is related to decrease concentration of C-reactive protein (CRP), proinflammatory eicosanoids, cytokines, chemokines and other inflammation biomarkers. Many of clinical trials have shown the beneficial effect of dietary supplementation with omega-3 fatty acids in inflammatory and autoimmune diseases in human, including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), multiple sclerosis (MS) and migraine headaches. Therefore, omega-3 fatty acids as an alternative therapy can be potentially important. This review focuses on the pathogenesis of a migraine, with an emphasis on the role of omega-3 fatty acid and its
molecular mechanisms.
Keywords :
Omega-3 Fatty Acids , Migraine , Neuroinflammation , Headache
