Author/Authors :
Jilanchi, Sima Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Nematbakhsh, Mehdi Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Mazaheri, Safoora Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Talebi, Ardeshir Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Zolfaghari, Behzad Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Pezeshki, Zahra Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Eshraghi-Jazi, Fatemeh Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Moeini, Maryam Water and Electrolytes Research Center - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Background: Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats.
Methods: Twenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for 9 days, and from day 3 on, they also received cisplatin (CDDP) (2.5 mg/kg) daily. Group 3 was treated
as group 1 expects saline instead of PFE, and group 4 received PFE (25 mg/kg/day) alone.
Results: Cisplatin alone increased the serum levels of blood urea nitrogen, creatinine, and nitrite; and kidney tissue damage score and kidney weight. However, PFE not only did not ameliorate the induced nephrotoxicity, but also aggravated renal tissue damage.
Conclusions: Pomegranate extract as an antioxidant did not ameliorate CDDP-induced nephrotoxicity in female rats.
Keywords :
Cisplatin , female rats , nephrotoxicity , pomegranate
