Author/Authors :
Mirsepassi, Zahra Department of Psychiatry - Razi Psychiatric Hospital - University of Social Welfare and Rehabilitation Sciences, Tehran , Mazinani, Robabeh Department of Psychiatry - Razi Psychiatric Hospital - University of Social Welfare and Rehabilitation Sciences, Tehran , Fadai, Farbod Department of Psychiatry - Razi Psychiatric Hospital - University of Social Welfare and Rehabilitation Sciences, Tehran , Alibeigi, Neda Department of Psychiatry - Razi Psychiatric Hospital - University of Social Welfare and Rehabilitation Sciences, Tehran , Nazeri-Astaneh, Ali Department of Psychiatry - Razi Psychiatric Hospital - University of Social Welfare and Rehabilitation Sciences, Tehran
Abstract :
Objective: The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania.
Methods: In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic
episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment
responses were assessed by Young Mania Rating Scale (YMRS) weekly.
Results: In both intervention and control groups, YMRS score had significant decline after 8 weeks
(p < 0.001), but there was no statistically significant difference between the two groups (p = 0.419). The highest
score decline was after two weeks. YMRS score at baseline did not have statistically significant difference
between the intervention and control groups (p = 0.709).
Conclusions: This study failed to show antimanic efficacy of adjunctive topiramate in the treatment of those
with acute manic.
Keywords :
Lithium , Topiramate , Mania , Treatment
