Author/Authors :
Amini-Lari, Mahmood Shiraz University of Medical Sciences, Shiraz , Alammehrjerdi, Zahra Tehran University of Medical Sciences, Tehran , Ameli, Fatemeh Shiraz University of Medical Sciences, Shiraz , Joulaei, Hassan Shiraz University of Medical Sciences, Shiraz , Daneshmand, Reza University of SocialWelfare and Rehabilitation Sciences, Tehran , Faramarzi, Hossain Larestan University of Medical Sciences - Larestan, Fars , Bakhtiyari, Hamid-Reza Shiraz University of Medical Sciences, Shiraz , Samadi, Roya Department of Psychiatry - Mashhad University of Medical Sciences, Mashhad
Abstract :
Background: Opiate use on a stable methadone dose is a health concern in Iran (Persia). Cognitive-behavioral therapy (CBT) is a
suggested treatment for this problem.
Objectives: The study aimed to assess the CBT effectiveness in the treatment of regular opiate use on a stable methadone dose in
Shiraz, near the Persian Gulf of Iran.
Methods: The study design was a multicenter randomized controlled trial. The study was conducted at two methadone clinics
during 2015. Overall, 118 patients who were regular opiate users were selected. Participants were randomly assigned (1:1) to receive
either CBT (n = 59) or remain in a control condition (n = 59). The Opiate Treatment Index, Contemplation Ladder and Severity of
Dependence Scale were completed at baseline, post-treatment and a three-month follow-up. The primary outcome was the reduced
mean score of regular opiate use. Other outcomes included an increased readiness to reduce opiate use and reduced severity of
opiate dependence. Data were analyzed performing intentions-to-treat analyses, independent samples t-tests and Wilcoxon Rank-
Sum tests.
Results: CBT significantly reduced opiate use (z = 3.73, P = 0.01, d = 0.89) and the severity of opiate dependence (z = 7.36, P = 0.01, d =
0.64) after four weeks of treatment. Readiness to reduce opiate use significantly increased (t (116) = 9.55, P = 0.01, d = 0.81) over the
same time. All study results remained stable at three-month follow-up while no significant change was found in the control group.
Conclusions: CBT can be used as an effective intervention to reduce regular opiate use on a stable methadone dose. A larger study
with more Persian participants and a six-month follow-up is suggested.
Keywords :
Cognitive-Behavioral Therapy , Iran , Methadone Therapy , Substance Use Disorders