Title of article :
Preferential Solvation of Fenofibrate in (Ethanol or Acetone) + Water Mixtures at 298.15 K
Author/Authors :
Jouyban, Abolghasem Pharmaceutical Analysis Research Center and Faculty of Pharmacy - Tabriz University of Medical Sciences - Tabriz , Martinez, Fleming Grupo de Investigaciones Farmacéutico-Fisicoquímicas - Departamento de Farmacia, Facultad de Ciencias - Universidad Nacional de Colombia –Sede Bogotá - Cra. 30 No. 45-03 - Bogotá D.C. - COLOMBIA , Acree Jr., William E Department of Chemistry - University of North Texas - Denton - TX 76203-5070 - USA
Abstract :
The aim of this communication was to expand the results of numerical analyses
performed by Sun et al. on their experimental solubility of fenofibrate in aqueous mixtures of
ethanol and acetone at 298.15 K, in terms of the evaluation of the preferential solvation of
this compound by the organic solvents and water in the saturated mixtures based on the inverse
Kirkwood-Buff integrals (IKBI). According to the results, this drug is preferentially solvated
by water in water-rich mixtures but preferentially solvated by the cosolvents in mixtures with
intermediate composition and also in cosolvent-rich mixtures. Preferential solvation by water
in water-rich mixtures may be due to hydrophobic hydration around non-polar moieties of this drug.
Moreover, it is conjecturable that in regions with preferential solvation by the cosolvents the drug
is acting as Lewis acid with the cosolvent molecules because they are more basic than water.
Keywords :
IKBI , Preferential solvation , Jouyban-Acree model , Cosolvent + water mixtures , Fenofibrate
Journal title :
Astroparticle Physics
