Author/Authors :
Shaygannejad, Vahid Department of Neurology and Isfahan Neurosciences Research Center , Tahani, Soheil Department of Neurology and Isfahan Neurosciences Research Center , Ashtari, Fereshteh Department of Neurology and Isfahan Neurosciences Research Center , Vesal, Sahar Department of Neurology and Isfahan Neurosciences Research Center , Dehghani, Leila Department of Neurology and Isfahan Neurosciences Research Center , Montazeri, Saeed Medical Student Research Center - Isfahan University of Medical Sciences - Isfahan , Jamshidian, Azam Immunology and Microbiology Department - Faculty of Medicine - Shahrekord University of Medical Sciences - Shahrekord , Gharagozloo, Marjan Department of Immunology - School of Medicine - Isfahan University of Medical Sciences , Hasheminia, Javad Department of Medical Sciences - Najafabad Branch - Islamic Azad University - Isfahan
Abstract :
Background: Midkine (MK) is a heparin-binding growth factor with promoting effects
in inflammatory responses through enhancing leukocytes migration. Objective: To
study the correlation between MK serum levels and concentration of inflammatory
cytokines in Multiple Sclerosis (MS) patients. Methods: We evaluated the MK level
and its relationship with inflammatory cytokines (IL-17 and IL-23) and antiinflammatory
ones (IL-10 and TGF-β) in multiple sclerosis (MS) patients. The serum
concentrations of MK and cytokines were assessed by ELISA in 32 MS patients in
comparison with 32 healthy subjects. Results: Our data showed that the MK
concentration in MS patients is lower than healthy controls (341.15 ± 40.71 Pg/ml vs.
620.15 ± 98.61 Pg/ml, respectively, p=0.015). We also observed a significant decrease
in IL-10, IL-23, and TGF-β cytokine levels in MS patients. There was a significant
correlation between MK and IL-23 concentrations in our study (r = +0.829, p≤ 0.001).
Conclusion: These results confirm a role for MK in inflammatory reactions in MS.
Keywords :
IL-10 , TGF-β , Multiple Sclerosis , Midkine , IL-23 , IL-17
