Title of article :
Aqueous Humor and Serum Concentrations of Soluble MICA and MICB in Glaucoma Patients
Author/Authors :
Nowroozpoor-Dailami, Kiomars Department of Ophthalmology - Bou Ali Sina Hospital , Mirabi, Araz-Mohammad Department of Immunology - School of Medicine - Molecular and Cell Biology Research Center (MCBRC) - Mazandaran University of Medical Sciences - Sari , Tehrani, Mohsen Department of Immunology - School of Medicine - Molecular and Cell Biology Research Center (MCBRC) - Mazandaran University of Medical Sciences - Sari , Ajami, Abolghasem Department of Immunology - School of Medicine - Molecular and Cell Biology Research Center (MCBRC) - Mazandaran University of Medical Sciences - Sari
Abstract :
Background: Immune reactions have been reported to be involved in the destruction of
retinal ganglion cells (RGCs) in glaucoma. Objective: To investigate the role of major
histocompatibility complex class I-related chain A and B (MICA and MICB) molecules
in the pathogenesis of glaucoma. Methods: Aqueous humor and serum samples from 15
glaucoma patients and 45 patients with cataract, undergoing ocular surgery, were
obtained. The concentrations of MICA and MICB molecules in all samples were
measured using ELISA. Results: Both MICA and MICB concentrations were higher in
the aqueous humor of patients with glaucoma compared to those with cataract (p=0.013
and p=0.004, respectively); however, in the serum samples, no significant differences
were observed. Conclusions: Increased intraocular pressure may be associated with
increased expression of the MICA and MICB molecules, which could initiate the
destruction of RGCs and consequent development of glaucoma.
Keywords :
Aqueous Humor , MICB , MICA , Glaucoma
Journal title :
Astroparticle Physics
