• Title of article

    SHORT PAPER IL-6/IL-10 Ratio as A Prognostic and Predictive Marker of the Severity of Inherited Epidermolysis Bullosa

  • Author/Authors

    Tampoia, Marilina Clinical Pathology Laboratory - Polyclinic of Bari - Department of Biomedical Sciences and Human Oncolog - University of Bari - Piazza Giulio Cesare 11 - 70124 Bari - Italy , Fumarulo, Ruggiero Clinical Pathology Laboratory - Polyclinic of Bari - Department of Biomedical Sciences and Human Oncolog - University of Bari - Piazza Giulio Cesare 11 - 70124 Bari - Italy , Morrone, Marella Clinical Pathology Laboratory - Polyclinic of Bari - Department of Biomedical Sciences and Human Oncolog - University of Bari - Piazza Giulio Cesare 11 - 70124 Bari - Italy , Abbracciavento, Letizia Clinical Pathology Laboratory - Polyclinic of Bari - Department of Biomedical Sciences and Human Oncolog - University of Bari - Piazza Giulio Cesare 11 - 70124 Bari - Italy

  • Pages
    10
  • From page
    340
  • To page
    349
  • Abstract
    Background: Recent studies have shown that cytokines have an important role in the pathogenesis of inflammatory diseases and can be used as prognostic markers. Objective: To evaluate the IL-6/IL-10 ratio in patients with Inherited Epidermolysis Bullosa (EB) as a prognostic marker. Methods: Serum levels of IL-6 and IL-10 were measured in 13 patients with recessive dystrophic EB (RDEB) as well as 10 with EB Simplex (EBS), and in 18 healthy subjects. Receiver Operating Characteristics (ROC) analyses were used to assess the diagnostic accuracy of the IL-6/IL-10 ratio for detecting severe form of EB. Results: The IL-6/IL-10 ratio was statistically higher in RDEB patients than in EBS patients and healthy subjects. The IL-6/IL-10 ratio significantly correlated with BEBS score. Conclusion: Our findings suggest that IL- 6/IL-10 ratio >5.6 has a good diagnostic accuracy to identify patients with the highest severity of disease.
  • Keywords
    Anti-Skin Autoantibodies , Birmingham Epidermolysis Bullosa Severity Score , Cytokines , IL-6/IL-10 Ratio , Inherited Epidermolysis Bullosa
  • Journal title
    Astroparticle Physics
  • Serial Year
    2017
  • Record number

    2429429

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2429429