Author/Authors :
Bidram, Penman Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Roghani, Farshad Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Sanei, Hamid Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Golabchi, Allahyar Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Mousavi, Mehdi Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Hajiannejad, Alireza Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Pourheidar, Behrouz Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Mohseni Badalabadi, Mehdi Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Akhbari, Mohammadreza Shaheed Beheshti Hospital - Kashan University of Medical Sciences, Kashan , Gharaati, Maryam Isfahan University of Medical Sciences, Isfahan , Salesi, Asieh Department of Statistics - Allameh Tabatabai University, Tehran , Hedayati, Zahraparin Department of Nephrology - Isfahan University of Medical Sciences, Isfahan
Abstract :
Background: Contrast induced nephropathy (CIN) is one of the most common complications after radiographic procedures using
intravascular radiocontrast media. The aim of the current study was to assess the effect of atorvastatin on prevention of CIN in
patients undergoing coronary angiography. Materials and Methods: In a clinical trial study, 200 patients referred for angiography
were randomly divided into two groups of using 80 mg atorvastatin and placebo before the procedure. Furthermore, 100 patients
who were under chronic treatment of statins were included as the third group. Serum creatinine (Scr) levels before and after the
procedure were evaluated and incidence of CIN (post-procedural Scr of >0.5 mg/dl or >25% from baseline) was assessed. Results:
Mean age of the participants was 60.06 ± 0.69 years and 276 (92%) were male. There were no significant differences between group
with respect to age and gender. In pre-operation atorvastatin, placebo and long term statin groups, the incidence of CIN was 1%,
2% and 1%, and mean changes of Glomerular filtration rate (GFR) was 3.68 ± 1.32, −0.77 ± 1.21 and 1.37 ± 0.86; and mean changes
of creatinine (Cr) was −0.05 ± 0.02, 0.02 ± 0.02 and −0.01 ± 0.01 respectively. respectively (P = 0.776, 0.026 and 0.041 respectively).
In pre-operation atorvastatin group, Cr decreased, and GFR increased significantly (P = 0.019 and 0.007 respectively). Conclusion:
pre-operation short term high dose atorvastatin use was associated with a significant decrease in serum Cr level and increase in
GFR after angiography.
Keywords :
prevention , contrast induced nephropathy , atorvastatin , Angiography
