Author/Authors :
Wang, Xiao-Bing Departments of Rheumatology and Pneumology - The First Affiliated Hospital of Wenzhou Medical University - Zhejiang, China , Zhu, Xiao-Chun Departments of Rheumatology and Pneumology - The First Affiliated Hospital of Wenzhou Medical University - Zhejiang, China , Huang, Xiao-Ying Departments of Rheumatology and Pneumology - The First Affiliated Hospital of Wenzhou Medical University - Zhejiang, China , Ye, Wen-Jing Departments of Rheumatology and Pneumology - The First Affiliated Hospital of Wenzhou Medical University - Zhejiang, China , Wang, Liang-Xing Departments of Rheumatology and Pneumology - The First Affiliated Hospital of Wenzhou Medical University - Zhejiang, China
Abstract :
Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion
can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits
nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for
regular screening for evidence of proximal tubular dysfunction and detailed bone metabolic investigations for prompt detection of ADV
nephrotoxicity is critically important to ensure timely drug withdrawal before the development of irreversible tubulointerstitial injury.
Keywords :
nephrotoxicity , hypophosphatemia , Fanconi syndrome , Adefovir
