Title of article :
Red and processed meat consumption and risk of glioma in adults: A systematic review and meta-analysis of observational studies
Author/Authors :
Esmaillzadeh, Ahmad Food Security Research Center - Department of Community Nutrition - School of Nutrition and Food Science - Isfahan University of Medical Sciences, Isfahan , Saneei, Parvane Food Security Research Center - Department of Community Nutrition - School of Nutrition and Food Science - Isfahan University of Medical Sciences, Isfahan , Willett, Walter Department of Nutrition and Epidemiology- Harvard School of Public Health - Boston, USA
Abstract :
Background: These findings from several observational studies, investigated the association between red meat consumption and gliomas,
were inconsistent. We conducted a systematic review and meta-analysis of observational studies to summarize available date on the
relation between meat intake and risk of glioma. Materials and Methods: A systematic literature search of relevant reports published
until May 2014 of the PubMed/Medline, ISI Web of Knowledge, Excerpta Medica database, Ovid database, Google Scholar, and Scopus
databases was conducted. From 723 articles yielded in the preliminary literature search, data from eighteen publications (14 case-control,
three cohort, and one nested case-control study) on unprocessed red meat, processed meat, and/or total red meat consumption in
relation to glioma in adults were included in the analysis. Quality assessment of studies was performed. Random effects model was used
to conduct the meta-analysis. Results: We found a positive significant association between unprocessed red meat intake and risk of
glioma (relative risk [RR] = 1.30; 95% confidence interval [CI]: 1.08-1.58) after excluding three studies with uncertain type of brain cancer.
This analysis included only one cohort study which revealed no relation between unprocessed red meat intake and glioma (RR = 1.75;
95% CI: 0.35-8.77). Consumption of processed meats was not related to increased risk of glioma in population-based case-control
studies (RR = 1.26; 95% CI: 1.05-1.51) and reduced risk in hospital-based case-controls (RR = 0.79; 95% CI: 0.65-0.97). No significant
association was seen between processed red meat intake and risk of glioma in cohort studies (RR: 1.08; 95% CI: 0.84-1.37). Total red
meat consumption was not associated with risk of adult glioma in case-control or cohort studies. Conclusion: In this meta-analysis of
18 observational studies, we found a modest positive association between unprocessed red meat intake and risk of gliomas based almost
entirely on case-control studies. Processed red meat was overall not associated with risk of gliomas in case-control or cohort studies.
Keywords :
risk factor , red meat , processed meat , meta-analysis , Glioma
Journal title :
Astroparticle Physics
