Comparison of clinicopathologic variables in coexistence cancers of the endometrium and ovary: A review of 55 cases in an academic center in Iran

Background: Th e coexistence primary cancers of the endometrium and ovary are relatively uncommon. Th e purpose of this study was to characterize patients diagnosed primary synchronous endometrial and ovarian cancer (SEOC), endometrial cancer (EC) with ovarian metastasis, and ovarian cancer (OC) with endometrial metastasis and compare clinicopathologic variables and prognosis. Materials and Methods: All the patients with diagnosis of both endometrium and OC, who hospitalized between 2002 and 2012 in an academic center affi liated to Tehran University of Medical Sciences, were evaluated with respect to diff erent clinicopathologic variables, follow-up times, and outcomes. Results: Fifty-fi ve patients had been diagnosed with both endometrium and OC. 17, 26, and 12 patients were diagnosed as SEOC, EC, and OC, respectively. Th e frequency of abnormal uterine bleeding was signifi cantly lower in OC (16.7%) compared to others (58.8% in SEOC and 53.8% in EC). However, the abdominal/pelvic pain was signifi cantly higher in OC (50%) compared to others (35.3% in SEOC and 34.6% in EC) (P < 0.05). Complex atypical hyperplasia (87.5%), endometriosis (88.8%), and endometrioid carcinoma (54.5%) was observed most in SEOC group. Th e duration of follow-up time was between 3 and 171 months with a mean of 16 months. Th ere was no death in SEOC who followed. Survivals of patients between three group were statistically signifi cant (P = 0.032). Conclusion: Our results showed that overall survival (OS) and progression-free survival (PFS) of SEOC patients is better than those with EC and OC (P = 0.032).