Biochemical changes in blood of type 2 diabetes with and without metabolic syndrome and their association with metabolic syndrome components

Background: Multiple factors are involved in the development and progression of type 2 diabetes mellitus (DMII) to DMII with metabolic syndrome (MetS) and cardiovascular complications. To identify some of these factors, we aim to investigate the changes in erythrocyte membrane Na+/K+-ATPase activity, serum glucose, insulin, lipid profi le, hemoglobin A1C (HbA1c), high-sensitivity C-reactive protein (hs-CRP), anthropometric measurements, and blood pressure in DMII with and without MetS. Materials and Methods: Th is cross-sectional study comprised 155 male subjects distributed into three groups as healthy controls (50 non-DMII volunteers), Group I (50 DMII without MetS), and Group II (55 DMII with MetS). Fasting blood samples were taken for the measurement of glucose, insulin, HbA1c, hs-CRP and lipid profi le. Na+/K+-ATPase activity was determined in erythrocyte ghost. Results: Na+/K+-ATPase activity was signifi cantly decreased in DMII groups compared with controls. No signifi cant diff erence was shown in Na+/K+-ATPase activity between DMII groups. Total ATPase activity, total cholesterol and low-density lipoproteincholesterol levels were similar in the three groups. Levels of insulin, hs-CRP, triacylglycerols, systolic blood pressure, weight, waist and hip circumference, waist/hip ratio, and body mass index were signifi cantly elevated and high-density lipoprotein-cholesterol signifi cantly decreased only in Group II. Signifi cant diff erences in serum glucose and hip circumference were seen between the groups. No signifi cant diff erences in HbA1c levels were observed between DMII groups. Conclusion: Changes in many of the measured risk factors that occurred only in Group II compared with controls and Group I may provide an explanation of how DMII progresses to DMII with MetS and future cardiovascular complications.