Author/Authors :
Majidinejad, Saeed Isfahan University of Medical Sciences, Isfahan , Malekmohammad, Maryam Isfahan University of Medical Sciences, Isfahan , Kajbaf, Abdollah Isfahan University of Medical Sciences, Isfahan , Khodadoostan, Mahsa Isfahan University of Medical Sciences, Isfahan , Dolatkhah, Shahaboddin Isfahan University of Medical Sciences, Isfahan , Kajbaf, Mohammad Hossein Isfahan University of Medical Sciences, Isfahan , Adibi, Peiman Isfahan University of Medical Sciences, Isfahan
Abstract :
Background: A suitable sedative status during gastro-enteric endoscopies results in better physicians’ approach and more stable
view of internal organs. Therefore, we evaluated the effect of ketamine for sedation in endoscopic procedures of adult patients.
Materials and Methods: Patients who were candidates for gastro-enteric endoscopy during the years 2014-2015 were included into
the study and divided into two groups of case (administered 5 mg/kg of oral ketamine half an hour before initiation of the procedure)
and control (administered placebo in a same pattern). After endoscopy, patients and physicians’ satisfaction of sedation was assessed.
SPSS-22 was used for data analysis. Results: Eighty-six patients participated into the study of which divided into each groups. The
pain and discomfort scores were 2.4 ± 1.8 and 5.81 ± 1.48 in case and control groups, respectively, (P < 0.001). Mann-Whitney test
revealed statistical difference among groups about physician’s satisfaction of sedation during endoscopy (P < 0.001). Patients who
received ketamine had better sedative status (P < 0.001). None of the patients in the case group was completely awake but all of the
patients in the control group were awake. The number of retching during endoscopy showed that individuals in the control group had
more frequent retching episodes (P = 0.04). Conclusion: Low-dose oral administration of ketamine could make a satisfied sedation
for gastro-enteric endoscopy.
