Title of article
The effect of glutamine intake on complications of colorectal and colon cancer treatment: A systematic review
Author/Authors
Ramezani Jolfaie, Nahid Department of Community Nutrition- School of Nutrition and Food Science - Food Security Research Center - Isfahan University of Medical Sciences , Mirzaie, Safiye Department of Community Nutrition- School of Nutrition and Food Science - Food Security Research Center - Isfahan University of Medical Sciences , Ghiasvand, Reza Department of Community Nutrition- School of Nutrition and Food Science - Food Security Research Center - Isfahan University of Medical Sciences , Askari, Gholamreza Department of Community Nutrition- School of Nutrition and Food Science - Food Security Research Center - Isfahan University of Medical Sciences , Miraghajani, Maryam Department of Community Nutrition- School of Nutrition and Food Science - Food Security Research Center - Isfahan University of Medical Sciences
Pages
9
From page
910
To page
918
Abstract
Background: Improvement in complications of antitumor agents and surgery is important to enhance life quality and survival among
patients with colon and colorectal cancer. It has been reported that some dietary components such as glutamine (Gln) have beneficial
effects on these complications of cancer therapies. However, the results of studies are inconsistent in this area. We performed a review
on randomized controlled trials (RCTs) evaluating the effects of Gln intake on complications related to therapeutic strategies of the
colon and colorectal cancer. Materials and Methods: A systematic search was conducted in PubMed, Google Scholar, Cochrane
Library, and SID databases to find the relevant literature, published before July 2015. Results: Nine RCTs of 217 screened articles
were included in this systematic review. The results of the present review suggested that Gln intake among colon and colorectal
cancer patients could reduce some complications induced by chemotherapy such as gut mucositis and diarrhea and improve nitrogen
balance, immune system and wound healing after surgery, whereas benefits role of Gln on radiochemotherapy side effects were not
provided. Conclusion: The role of Gln intake on some improvement of complications induced by cancer therapeutic methods and
shorten the length of hospital stay may be promising and one that is worthy of further exploration.
Keywords
glutamine supplementation , colon colorectal , Cancer
Journal title
Astroparticle Physics
Serial Year
2015
Record number
2430514
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