Title of article :
Effects of three months treatment with sertraline on intraocular pressure and cup-to-disc ratio in patients with anxiety disorders/mixed anxiety and depressive disorder/major depressive disorder and without underlying eye disease
Author/Authors :
Hendouei, Narjes Department of Pharmacotherapy - Faculty of Pharmacy and Psychiatry and Behavioral Sciences Research Center - Addiction Institute - Mazandaran University of Medical Sciences, Sari , Farnia, Samaneh Psychiatry and Behavioral Sciences Research Center - Addiction Institute and Department of Psychiatry - Mazandaran University of Medical Sciences, Sari , Bazyari, Hamid Student Research Committee - Faculty of Pharmacy - Mazandaran University of Medical Sciences, Sari , Ahmadi, Hanieh Department of ophthalmology - School of medicine - Mazandaran University of Medical Sciences, Sari , Tabrizi, Nasim Department of Neurology - School of medicine - Mazandaran University of Medical Sciences, Sari , sharifi_razavi, Athena Department of Neurology - School of medicine - Mazandaran University of Medical Sciences, Sari
Abstract :
Exposure to selective serotonin reuptake inhibitors causes pupillary dilator muscle stimulation, active
mydriasis, rapid rise in the level of the intraocular pressure (IOP), damage to the optic nerve at the back of
the eye, and ultimately leads to acute angle closure glaucoma. The aim of this study was to assess the
effects of sertraline on the levels of IOP and cup-to-disc ratio (CDR) in patients with anxiety disorders or
mixed anxiety and depressive disorder or major depressive under daily treatment with sertraline and
without underlying eye disease for three months. In this study,30 eligible patients in the sertraline group
and 30 healthy volunteers in the control group include the study and were referred to an ophthalmologist.
Ophthalmologic examinations were assessed at the baseline and on the first and third months of the
study. The average daily dose of sertraline was 95±2.5 mg.During the study, the IOP changes in the
sertraline and control groups were 0.26±0.43 and 0.00±0.00 mmHg (p<0.001, p=NS) respectively and the
CDR changes in sertraline and control groups were 0.03±0.05 and -0.01±0.05 (p=0.002, p=0.03)
respectively. There was a significant difference in the IOP and CDR increasement between two groups ([F
(1.7, 104.2) = 3.7, p = 0.03] and [F (2, 116) = 8.3, p < 0.001] respectively). In the present study, although
changes in the IOP and CDR levels in the sertraline group were significant and was equal the daily change
in the persons without glaucoma or patients with normal-tension glaucoma, but the slight and continuous
increase in the IOP level associated with changes in pupil size and CDR, especially in patients at risk of
glaucoma in the long term, can cause a disruption in hydrodynamic homeostasis. More studies with longer
duration and different dosage of sertraline need to confirm our results.
Keywords :
Cup-to-disc ratio , Intraocular pressure , reuptake inhibitors , Selective serotonin
Journal title :
Astroparticle Physics
