Analysis of CRP, Vitamin D and Metabolic Factors in Non-obese Patients with Polycystic Ovary Syndrome: a Cross Sectional Study in Imam Khomeini Hospital, Ahvaz

Background and Objectives: The polycystic ovary syndrome (PCOS) is one of the most common diseases diagnosed in women of childbearing age which is associated with increased risk of metabolic complications, including cardiovascular disease. Increasing C-reactive protein (CRP) as an inflammatory factor is common in these patients. In addition, vitamin D deficiency is quite common among females with PCOS. The aim of this study is to determine the relationship of CRP levels with vitamin D and metabolic factors in Non-obese Patients with PCOS. Materials and Methods: This experimental study was done on 100 non-obese 20-40 years old females (BMI<30) who were diagnosed with PCOS. Based on CRP levels, the females are categorized in two groups (normal CRP<0.8 mg/dl). The serum levels of HOMA-IRC, FBS, HDL-C, LDL-CHL, Vitamin D and CRP of participants in the study were measured. Then, collected data was analyzed through the SPSS Software (version. 23). In all analysis, the p-value is presumed to be less than 0.05. Results: The mean age of patients was 27.11±6.25. Patients in high CRP group, had significantly lower levels of HDL-C and higher Triglyceride (TG) compared to controls. In addition, the increase in CRP was associated with vitamin D deficiency. This was while no significant difference between the two groups of patients were observed in terms of insulin resistance. Conclusions: The findings of present study suggest that higher CRP levels are positively correlated with vitamin D and HDL-C deficiency as well as an increased TG levels in non-obese females with PCOS. These findings have significant implications for the understanding of how vitamin D deficiency can contribute to inflammatory and metabolic responses in patients with PCOS. A future study could assess the long-term implications of vitamin D supplementation on inflammation and metabolic outcome of patients with PCOS.