Author/Authors :
Farjadian, SH Department of Immunology - Hematology Research Cente - Department of Pediatrics - Shiraz University of Medical Sciences, Shiraz , Azad, F Department of Immunology - Hematology Research Cente - Department of Pediatrics - Shiraz University of Medical Sciences, Shiraz , Bordbar, MR Department of Immunology - Hematology Research Cente - Department of Pediatrics - Shiraz University of Medical Sciences, Shiraz , Karimi, M Department of Immunology - Hematology Research Cente - Department of Pediatrics - Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: Fanconi anemia (FA) is a chromosomal breakage disorder characterized by familial aplastic anemia
(AA), various congenital anomalies, and a characteristic chromosomal response to clastogenic stress.
Methods: In this study, chromosome breakage test was performed for 38 patients suspected of having FA
and age-matched controls.
Results: According to the results, ten patients were considered as FA cases and 15 patients with no chromosomal
breaks were considered as AA.
Conclusion: Differentiation of FA from AA is very important because the primary treatment is different. This
test should be done in every primary presentation of AA.
