Pleurodesic Effect of Bioglass in Experimental Rabbits

Background: Pleurodesis has been a widely used treatment option for recurrent and persistent pleural effusions and air leaks. However, an ideal pleurodesing agent has not been found yet. The purpose of this study was to investigate the dose dependent effects of bioglass on pleurodesis. Methods: Fifty six male, New Zealand rabbits weighing 3000-3500 gr were used in this study. After right chest tube insertion, 35, 70, 150, and 400 mg/kg bioglass; and 70 and 400 mg/kg talc in saline solution were administered through the chest tube into the pleural cavity. One ml/kg isotonic saline solution was administered in the control group. After 4 weeks, the rabbits were sacrificed for pleurodesis evaluation. Results: Bioglass 400 and Talc 400 had a higher pleurodesic effect than the other doses with no statistically significant difference. Local inflammation, fibrosis and particle dissemination were significantly higher in Bioglass 400 and Talc 400 than in the controls. Talc 400 caused more inflammation and more particle accumulation than those by bioglass 400. Conclusions: Bioglass may be a valuable pleurodesic agent. However, further studies are needed for more definitive results.