Title of article :
The Detection of HDL receptor on platelet surface in patients with Coronary artery disease (CAD)
Author/Authors :
Nehzati, Parisa Department of Hematology and Blood Banking - School of Allied Medical Sciecnes - Shahid Beheshti University of Medical Sciences , Hamidpour, Mohsen Department of Hematology and Blood Banking - School of Allied Medical Sciecnes - Shahid Beheshti University of Medical Sciences , Bashash, Davod Department of Hematology and Blood Banking - School of Allied Medical Sciecnes - Shahid Beheshti University of Medical Sciences , Nikoogoftar, Mahin Department of Hematology and Blood Banking - Iranian Blood Transfusion Organization (IBTO) , Hedari, Mohammad Reza Department of Internal Medicine - School of Medicine - Shahid Beheshti University of Medical Sciences , Khadem Mabodi, Ali Akbar Department of Biostatics - School of Allied Medical Sciencces - Shahid Beheshti University of Medical Sciences
Abstract :
The human scavenger receptor B1 (hSR-B1/CLA) is a HDL receptor with various anti-atherogenic
functions which is expressed on the platelet surface. The anti thrombotic function of HDL includes the
modulation of platelet reactivity, coagulation, and endothelial function. The goal of this study is to detect the
level of HDL receptor on platelets of CAD patients with atherosclerotic disease. Expressions of the hSRB1
receptor on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls was detected
using flow cytometry. Moreover, the lipid panel tests were assayed by Chemistry auto analyzer and
compared with healthy controls. Our findings show that abundance of hSR-B1/CLA-1 was significantly
reduced on the surface of platelets from CAD patients with atherosclerotic disease compared with healthy
control (6/8 % vs. 13/6 %), (P <0,001).
The HDL receptor (hSR-B1/CLA-1) expression on platelets inversely correlates with the risk of coronary
heart disease. Our findings suggest that determining the level of hSR-B1/CLA-1 on the platelets may be a
useful laboratory marker for CAD investigation.
Keywords :
CAD , Platelet , HDL Receptor
Journal title :
Astroparticle Physics
