Author/Authors :
Karimian, Farid Shahid Beheshti University of Medical Sciences, Tehran , Faramarzi, Amir Shahid Beheshti University of Medical Sciences, Tehran , Fekri, Sahba Shahid Beheshti University of Medical Sciences, Tehran , Mohammad-Rabie, Hossein Shahid Beheshti University of Medical Sciences, Tehran , Najdi, Danial Shahid Beheshti University of Medical Sciences, Tehran , Doozandeh, Azadeh Shahid Beheshti University of Medical Sciences, Tehran , Delfaza-Baher, Siamak Shahid Beheshti University of Medical Sciences, Tehran , Yaseri, Mehdi Department of Epidemiology and Biostatistics - Tehran University of Medical Sciences, Tehran
Abstract :
Purpose: To compare the efficacy and side effects of loteprednol versus fluorometholone after myopic
photorefractive keratectomy (PRK).
Methods: One hundred and twenty four eyes of 62 patients who underwent PRK were enrolled in this
study. One eye of each subject was randomized to receive loteprednol 0.5% and the fellow eye was given
fluorometholone 0.1%. Patients were followed up for three months.
Results: There was no significant difference in uncorrected distance visual acuity (UDVA), corrected distance
visual acuity (CDVA), manifest refraction, corneal haze, intraocular pressure (IOP), and ocular discomfort and
redness between groups at the final visit. At 3 months postoperatively, 20/25 or better UDVA was achieved
in 95% of the loteprednol group and 92% of the fluorometholone group (P > 0.05). There was neither visually
significant corneal haze nor ocular hypertension (IOP rise > 10 mmHg or IOP > 21 mmHg) in any group.
Conclusion: The efficacy and side effects of loteprednol 0.5% and fluorometholone 0.1% after myopic PRK
are comparable.
Keywords :
Corneal Haze , Fluorometholone , Intraocular Pressure , Loteprednol , Photorefractive Keratectomy
